Transducing Hedgehog: the story so far

Transducing Hedgehog: the story so far.

The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause...

Curcumin: the story so far.

Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric. It possesses diverse anti-inflammatory and anti-cancer properties following oral or topical administration. Apart from curcumin's potent antioxidant capacity at neutral and acidic pH, its mechanisms of action include inhibition of several cell signalling pathways at multiple levels, effects on cellular enzymes s...

MetateM: The Story so Far

METATEM is a simple programming language based on the direct execution of temporal logic statements. It was introduced through a number of papers [35,2,3] culminating in a book collecting together work on the basic temporal language [5]. However, since that time, there has been a programme of research, carried out over a number of years, extending, adapting and applying the basic approach. In p...

Estrogen and cognition: the story so far.

ESTROGEN is a complex gonadal hormone that reportedly exhibits numerous neurobehavioral effects in both human volunteers and animals. Evidence from basic science and clinical research demonstrates that estrogen can enhance cognitive function of healthy older women as well asthose with Alzheimer’s disease (AD) (1–3). Although the biology of estrogen strongly supports its neuromodulatory and neur...

Milestones in Transplantation : the Story so Far